Ligand Binding: Molecular Mechanics Calculation of the Streptavidin-Biotin Rupture Force
نویسندگان
چکیده
منابع مشابه
Ligand Binding: Molecular Mechanics
The force required to rupture the streptavidin-biotin complex was calculated here by computer simulations. The computed force agrees well with that obtained by recent single molecule atomic force microscope experiments. These simulations suggest a detailed multiple-pathway rupture mechanism involving five major unbinding steps. Binding forces and specificity are attributed to a hydrogen bond ne...
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ژورنال
عنوان ژورنال: Science
سال: 1996
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.271.5251.997